ORIGINAL ARTICLE: Brief Report: VEGF Inhibition and Renal Thrombotic Microangiopathy
Mercredi 12 Mars 2008 - 06:55 - 8 mois, 3 semaines depuis
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Santé
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New England Journal of Medicin
In six patients who received bevacizumab, a humanized monoclonal antibody against vascular endothelial growth factor (VEGF), proteinuria subsequently developed, and thrombotic microangiopathy was shown on renal biopsy. In a murine model, the authors showed that using conditional gene targeting to ablate the VEGF gene from renal podocytes can trigger thrombotic microangiopathy. This finding suggests that glomerular injury from bevacizumab may be due to the direct targeting of VEGF.